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Heart Rate Increases Are Dose-Dependent Retatrutide raises resting heart rate in a dose-dependent pattern, peaking around week 24 and partially declining afterward

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It highlights the importance of appropriate dosing, monitoring side effects, and avoiding unregulated or non-prescribed use, particularly given the increasing public demand for these treatments [3]

Mild constipation may improve with hydration, fiber, movement, and clinician-approved support

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The net effect of potential receptor activation in the context of other metabolic changes is unclear and requires further investigation